Safety Profile of Mefenamic Acid

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Established Safety Record

Mefenamic acid has a well-established safety profile supported by over six decades of clinical use. Multiple clinical trials, including direct comparisons with ibuprofen and paracetamol, position mefenamic acid among the safest available NSAIDs.

Pediatric Safety Data

Clinical studies in pediatric patients demonstrate that mefenamic acid has a favorable safety and tolerability profile comparable to paracetamol and ibuprofen.

COX₂ Selectivity Advantage

Due to its preferential COX₂ inhibition, mefenamic acid is primarily associated with only minor GI effects, which are more likely when the drug is taken without adequate food or sufficient water. This property is associated with a lower rate of GI-related hospital admissions compared with other NSAIDs, including those with GI-protective claims.

Reference: Pai U, Venkata R A, Shah A, et al. Cureus. 2025; 17(7) : 1-19

Products:

MEFTAL-P Suspension is indicated for the symptomatic treatment of fever in children above 6 months of age.

URL Reference:  https://www.meftal.com/product/meftal-p-mefenamic-acid-suspension